Article

Aβ-Overlapping Ectodomain Binding of the Clinical-Stage TREM2 Agonist VG-3927

2026-03-05

Abstract excerpt

Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial immune receptor genetically and functionally linked to Alzheimer’s disease (AD). VG-3927, the first clinical-stage small-molecule TREM2 agonist, has been proposed to function as a transmembrane molecular glue and positive allosteric modulator (PAM). Whether it directly engages the extracellular ligand-recognition surface of TREM2 remains unkn...

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Literature Corpus work: 98255c54-512a-5eba-b841-69a4169fc1eb
DOI: 10.64898/2026.03.02.709194

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