Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular recognition of the interaction between ApoE and the TREM2 protein

1 Jan 2022

Abstract excerpt

Abstract Alzheimer’s disease (AD) is the most common type of dementia. The ε4 allele of the apolipoprotein E ( ApoE ) gene is the strongest known genetic risk factor for late-onset AD. Triggering receptor expressed on myeloid cells 2 (TREM2) is another important risk factor affecting the AD process after ApoE . Emerging evidence has identified TREM2 as a putative receptor for ApoE, raising the possibility that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Inflammation biomarkers and pathways
Share to Medicinal Plants and Neuroprotection
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35582645
DOI: 10.1515/tnsci-2022-0218

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular recognition of the interaction between ApoE and the TREM2 proteinPMID 35582645Read ↗

Docking and Molecular Dynamic Simulation of ApoE isoforms to Trem2Semantic proximity Read ↗

Evidence of trem2 variant associated with triple risk of Alzheimer's disease.Semantic proximity Read ↗

Molecular Dynamics simulations of TREM2 variants R47H and R62H show structural alterations at key binding regions leading to possible implications for mechanisms in Alzheimer’s disease.Semantic proximity Read ↗

Functional insights from biophysical study of TREM2 interactions with ApoE and Aβ <sub>1-42</sub>Semantic proximity Read ↗

Understanding the binding mechanisms of Alzheimer risk factor TREM2 in lipid bilayer using multi-scale molecular dynamics simulationsSemantic proximity Read ↗

XL-MS and De Novo Protein Design Identified a Common Motif for TREM2 BindingSemantic proximity Read ↗

Mechanistic insights into the deleterious roles of Nasu-Hakola disease associated TREM2 variantsSemantic proximity Read ↗

Mechanistic insights into the deleterious role of nasu-hakola disease associated TREM2 variantsSemantic proximity Read ↗

Dynamic insights into the effects of nonsynonymous polymorphisms (nsSNPs) on loss of TREM2 function.Semantic proximity Read ↗

Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple AD ligandsSemantic proximity Read ↗

Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligandsSemantic proximity Read ↗

The flexible stalk domain of sTREM2 modulates its interactions with brain-based phospholipidsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.