Article

TREM2 Activation by First-in-Class Direct Small Molecule Agonists: DEL Screening, Optimization, Biophysical Validation, and Functional Characterization

2025-05-27

Abstract excerpt

<h4>ABSTRACT</h4> Triggering receptor expressed on myeloid cells 2 (TREM2) is a key regulator of microglial function, and its loss-of-function variants are linked to Alzheimer’s disease (AD) and neurodegenerative disorders. While TREM2 activation is a promising therapeutic strategy, no small molecule agonists acting via direct TREM2 binding have been reported to date. Here, we describe the discovery of first-in-c...

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Literature Corpus work: f42a3b1e-e6ff-563c-a786-32b98724f513
DOI: 10.1101/2025.05.22.655617

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