Article

Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands

2024-09-12

Abstract excerpt

<title>Abstract</title> <p>TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have been identified, little is known regarding the structural details of how they engage. To better understand this, we created a protein library of 28 different TREM2 variants that could be used...

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Literature Corpus work: b6c1a46e-1be9-5bcf-8993-50a11a1476d2
DOI: 10.21203/rs.3.rs-4850141/v1

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