High affinity interactions and signal transduction between Aβ oligomers and TREM2

Abstract excerpt

<h4>ABSTRACT</h4> Rare coding variant in the Triggering receptor expressed on myeloid cells 2 (TREM2) are associated with increased risk for Alzheimer’s disease (AD), but how they confer this risk remains uncertain. We assessed binding of TREM2, AD associated TREM2 variants to various forms of Aβ and APOE in multiple assays. TREM2 interacts directly with various forms of Aβ, with highest affinity interactions obs...

Topics

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• Alzheimer Disease
• Amyloid beta-Peptides
• Cell Survival
• Disease Models, Animal
• Membrane Glycoproteins
• Mice
• Microglia
• Receptors, Immunologic

Identifiers and source

Literature Corpus work

68b3bf3e-f7ab-5364-a8b1-ebcfb7eac343

DOI

10.1101/269787