Article

CRISPR interference-based platform for multimodal genetic screens in human iPSC-derived neurons

2019-01-07

Abstract excerpt

<h4>SUMMARY</h4> CRISPR/Cas9-based functional genomics have transformed our ability to elucidate mammalian cell biology. However, most previous CRISPR-based screens were conducted in cancer cell lines, rather than healthy, differentiated cells. Here, we describe a CRISPR interference (CRISPRi)-based platform for genetic screens in human neurons derived from induced pluripotent stem cells (iPSCs). We demonstrate r...

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Literature Corpus work: 7260a994-28b2-5204-9c84-305cc3ad993b
DOI: 10.1101/513309

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