Article

Unexpected <i>XIST</i> Expression in Male Hearts Associates with Disease

2025-04-15

Abstract excerpt

XIST is a long non-coding RNA that mediates the process of X chromosome inactivation in females, and has not been previously observed in males outside of developmental, pathological, and ectopic contexts. We report the unprecedented endogenous expression of XIST in 226 male heart samples across 15 single-cell RNA sequencing studies. The male expression of XIST is specific to a rare cell type typically annotated...

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Literature Corpus work: af9144cd-d128-5ca2-9686-3f60e0496ef5
DOI: 10.1101/2025.04.09.648005

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