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CRISPR-SID: identifying EZH2 as a druggable target for desmoid tumors via <i>in vivo</i> dependency mapping

2019-04-01

Abstract excerpt

Cancer precision medicine implies identification of tumor-specific vulnerabilities associated with defined oncogenic pathways. Desmoid tumors are soft-tissue neoplasms strictly driven by Wnt signaling network hyperactivation. Despite this clearly defined genetic etiology and the strict and unique implication of the Wnt/β-catenin pathway, no specific molecular targets for these tumors have been identified. To addre...

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Literature Corpus work
2415c980-060f-5d3a-912b-487f5bddb181
DOI
10.1101/595769
Open publication

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CRISPR-SID: identifying EZH2 as a druggable target for desmoid tumors via <i>in vivo</i> dependency mappingDOI 10.1101/595769
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