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Article

Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis.

Leukemia - 1 Dec 2023

Tulkens Dieter, Boelens Marthe, Naert Thomas, Carron Marjolein, Demuynck Suzan, Dewaele Sylviane, Van Isterdael Gert, Creytens David, Pieters Tim, Goossens Steven, Van Vlierberghe Pieter, Vleminckx Kris

Abstract excerpt

CRISPR-mediated simultaneous targeting of candidate tumor suppressor genes in Xenopus tropicalis allows fast functional assessment of co-driver genes for various solid tumors. Genotyping of tumors that emerge in the mosaic mutant animals rapidly exposes the gene mutations under positive selection for tumor establishment. However, applying this simple approach to the blood lineage has not been attempted. Multiple...

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PMID: 37794102
DOI: 10.1038/s41375-023-02052-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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