Article

Identification of Cancer-Type-Specific CRISPR Targets Using DepMap Dependency Data

2026-04-21

Abstract excerpt

<title>Abstract</title> <p>CRISPR-Cas9 screening enables systematic identification of gene dependencies across diverse cancer cell lines. However, distinguishing lineage-specific vulnerabilities from broadly essential genes remains a key challenge for precision oncology. In this study, we analyzed DepMap 22Q1 data to develop a selectivity-centered computational framework for prioritizing cancer-type-specific depe...

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Literature Corpus work: 118a47e8-b7e0-57d2-80b7-d1817cb87617
DOI: 10.21203/rs.3.rs-9463556/v1

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