Article

A Selectivity-Based Analytical Strategy for Identifying Lineage-Specific Cancer Dependencies from DepMap Data

2026-05-19

Abstract excerpt

<title>Abstract</title> <p>Genome-wide CRISPR-Cas9 screening enables systematic identification of cancer dependencies, yet distinguishing lineage-specific vulnerabilities from broadly essential genes remains a central analytical challenge. Here we present a selectivity-based computational framework applied to the DepMap 26Q1 dataset, encompassing 1,208 cancer cell lines across 20 annotated lineages. Following var...

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Literature Corpus work: 7afefe37-12da-5a53-b809-b5729b951f93
DOI: 10.21203/rs.3.rs-9689757/v1

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