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Identifying chemogenetic interactions from CRISPR screens with drugZ

22 Aug 2019

Abstract excerpt

BACKGROUND: Chemogenetic profiling enables the identification of gene mutations that enhance or suppress the activity of chemical compounds. This knowledge provides insights into drug mechanism of action, genetic vulnerabilities, and resistance mechanisms, all of which may help stratify patient populations and improve drug efficacy. CRISPR-based screening enables sensitive detection of drug-gene interactions...

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PMID: 31439014
DOI: 10.1186/s13073-019-0665-3

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