Article

Prioritisation of oncology therapeutic targets using CRISPR-Cas9 screening

2018-12-20

Abstract excerpt

<h4>Summary</h4> Functional genomics approaches can overcome current limitations that hamper oncology drug development such as lack of robust target identification and clinical efficacy. Here we performed genome-scale CRISPR-Cas9 screens in 204 human cancer cell lines from 12 cancer-types and developed a data-driven framework to prioritise cancer therapeutic candidates. We integrated gene cell fitness effects wit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 569571b8-c9a1-55a3-b098-cb3886a50357
DOI: 10.1101/502005

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Prioritisation of oncology therapeutic targets using CRISPR-Cas9 screeningDOI 10.1101/502005Read

CRISPR-enhanced assessment of variants of unknown significance nominates oncology therapeutic targets and drug repositioning opportunitiesSemantic proximity Read

A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization.Semantic proximity Read

Comprehensive Genomic Dependency Landscape of Human Colon CancerSemantic proximity Read

Pharmacogenomic discovery of genetically targeted cancer therapies optimized against clinical outcomesSemantic proximity Read

Saturation genome editing of 11 codons and exon 13 of BRCA2 coupled with chemotherapeutic drug response accurately determines pathogenicity of variants.Semantic proximity Read

Genome wide-scale CRISPR-Cas9 knockout screens identify a fitness score for optimized risk stratification in colorectal cancerSemantic proximity Read

Using CRISPR-Cas9 to Dissect Cancer Mutations in Cell Lines.Semantic proximity Read

Identification of Cancer-Type-Specific CRISPR Targets Using DepMap Dependency DataSemantic proximity Read

Revolutionizing personalized cancer treatment: the synergy of next-generation sequencing and CRISPR/Cas9.Semantic proximity Read

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.Semantic proximity Read

Integrated cross-study datasets of genetic dependencies in cancerSemantic proximity Read

Mutational signatures are markers of drug sensitivity of cancer cells.Semantic proximity Read