Article

Identifying chemogenetic interactions from CRISPR knockout screens with drugZ

2017-12-12

Abstract excerpt

Chemogenetic profiling enables the identification of gene mutations that enhance or suppress the activity of chemical compounds. This knowledge provides insights into drug mechanism-of-action, genetic vulnerabilities, and resistance mechanisms, all of which may help stratify patient populations and improve drug efficacy. CRISPR-based screening enables sensitive detection of drug-gene interactions directly in human...

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Literature Corpus work: fec140fe-4f5f-5d41-a394-d5704e3f604c
DOI: 10.1101/232736

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