Article

A phylogenetic latent feature model for clonal deconvolution

2016-12-01

Abstract excerpt

Tumours develop in an evolutionary process, in which the accumulation of mutations produces subpopulations of cells with distinct mutational profiles, called clones. This process leads to the genetic heterogeneity widely observed in tumour sequencing data, but identifying the genotypes and frequencies of the different clones is still a major challenge. Here, we present Cloe, a phylogenetic latent feature model to...

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Literature Corpus work: 2398bfcb-6706-5c02-9a3b-a8f4d9867c73
DOI: 10.17863/cam.7628

Open publication

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