Article

PhyClone: Accurate Bayesian reconstruction of cancer phylogenies from bulk sequencing

2024-08-17

Abstract excerpt

<h4>Motivation</h4> Cancer is driven by somatic mutations that result in the expansion of genomically distinct sub-populations of cells called clones. Identifying the clonal composition of tumours and understanding the evolutionary relationships between clones is a crucial task in cancer genomics. Bulk DNA sequencing is commonly used for studying the clonal composition of tumours, but it is challenging to infer t...

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Literature Corpus work: 1c1a25aa-10e0-50c9-aefe-5722bb4d29d0
DOI: 10.1101/2024.08.14.607069

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