Article
QuantumClone: clonal assessment of functional mutations in cancer based on a genotype-aware method for clonal reconstruction.
Bioinformatics (Oxford, England) - 1 Jun 2018
Deveau Paul, Colmet Daage Leo, Oldridge Derek, Bernard Virginie, Bellini Angela, Chicard Mathieu, Clement Nathalie, Lapouble Eve, Combaret Valerie, Boland Anne, Meyer Vincent, Deleuze Jean-Francois, Janoueix-Lerosey Isabelle, Barillot Emmanuel, Delattre Olivier, Maris John M, Schleiermacher Gudrun, Boeva Valentina
Abstract excerpt
Motivation: In cancer, clonal evolution is assessed based on information coming from single nucleotide variants and copy number alterations. Nonetheless, existing methods often fail to accurately combine information from both sources to truthfully reconstruct clonal populations in a given tumor sample or in a set of tumor samples coming from the same patient. Moreover, previously published methods detect clones...
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