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Article

A statistical approach for tracking clonal dynamics in cancer using longitudinal next-generation sequencing data.

Bioinformatics (Oxford, England) - 19 Apr 2021

Vavoulis Dimitrios V, Cutts Anthony, Taylor Jenny C, Schuh Anna

Abstract excerpt

MOTIVATION: Tumours are composed of distinct cancer cell populations (clones), which continuously adapt to their local micro-environment. Standard methods for clonal deconvolution seek to identify groups of mutations and estimate the prevalence of each group in the tumour, while considering its purity and copy number profile. These methods have been applied on cross-sectional data and on longitudinal data after...

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PMID: 32722772
DOI: 10.1093/bioinformatics/btaa672
PMCID: PMC8055230

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