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Article

PyClone-VI: scalable inference of clonal population structures using whole genome data.

BMC bioinformatics - 10 Dec 2020

Gillis Sierra, Roth Andrew

Abstract excerpt

BACKGROUND: At diagnosis tumours are typically composed of a mixture of genomically distinct malignant cell populations. Bulk sequencing of tumour samples coupled with computational deconvolution can be used to identify these populations and study cancer evolution. Existing computational methods for populations deconvolution are slow and/or potentially inaccurate when applied to large datasets generated by whole...

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Identifiers

PMID: 33302872
DOI: 10.1186/s12859-020-03919-2
PMCID: PMC7730797

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