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Article

CLEMENT: genomic decomposition and reconstruction of non-tumor subclones.

Nucleic acids research - 12 Aug 2024

Chung Young-Soo, Kang Seungseok, Kim Jisu, Lee Sangbo, Kim Sangwoo

Abstract excerpt

Genome-level clonal decomposition of a single specimen has been widely studied; however, it is mostly limited to cancer research. In this study, we developed a new algorithm CLEMENT, which conducts accurate decomposition and reconstruction of multiple subclones in genome sequencing of non-tumor (normal) samples. CLEMENT employs the Expectation-Maximization (EM) algorithm with optimization strategies specific to...

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Identifiers

PMID: 38922688
DOI: 10.1093/nar/gkae527
PMCID: PMC11317173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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