Article

A statistical approach for tracking clonal dynamics in cancer using longitudinal next-generation sequencing data

2020-01-21

Abstract excerpt

<h4>ABSTRACT</h4> Tumours are composed of genotypically and phenotypically distinct cancer cell populations ( clones ), which are subject to a process of Darwinian evolution in response to changes in their local micro-environment, such as drug treatment. In a cancer patient, this process of continuous adaptation can be studied through next-generation sequencing of multiple tumour samples combined with appropriat...

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Literature Corpus work: c2c41207-2427-599c-b974-26bbc18e8f28
DOI: 10.1101/2020.01.20.913236

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