Article
Power and pitfalls of computational methods for inferring clone phylogenies and mutation orders from bulk sequencing data
2019-07-19
Abstract excerpt
<h4>Background</h4> Tumors harbor extensive genetic heterogeneity in the form of distinct clone genotypes that arise over time and across different tissues and regions of a cancer patient. Many computational methods produce clone phylogenies from population bulk sequencing data collected from multiple tumor samples. These clone phylogenies are used to infer mutation order and clone origin times during tumor progr...
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Identifiers and source
- Literature Corpus work
- 2f056975-0690-592c-b29c-cc9d663aaa5c
- DOI
- 10.1101/697318