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Article

High-definition reconstruction of clonal composition in cancer.

Cell reports - 12 Jun 2014

Fischer Andrej, Vázquez-García Ignacio, Illingworth Christopher J R, Mustonen Ville

Abstract excerpt

The extensive genetic heterogeneity of cancers can greatly affect therapy success due to the existence of subclonal mutations conferring resistance. However, the characterization of subclones in mixed-cell populations is computationally challenging due to the short length of sequence reads that are generated by current sequencing technologies. Here, we report cloneHD, a probabilistic algorithm for the performance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24882004
DOI: 10.1016/j.celrep.2014.04.055
PMCID: PMC4062932

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