Article

Clonal assessment of functional mutations in cancer based on a genotype-aware method for clonal reconstruction

2016-05-19

Abstract excerpt

In cancer, clonal evolution is characterized based on single nucleotide variants and copy number alterations. Nonetheless, previous methods failed to combine information from both sources to accurately reconstruct clonal populations in a given tumor sample or in a set of tumor samples coming from the same patient. Moreover, previous methods accepted as input all variants predicted by variant-callers, regardless of...

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Literature Corpus work: f52e4485-081b-5caf-b34e-e6686fa4c9bf
DOI: 10.1101/054346

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