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PhyClone: accurate Bayesian reconstruction of cancer phylogenies from bulk sequencing.

Bioinformatics (Oxford, England) - 1 Jul 2025

Hurtado Emilia, Bouchard-Côté Alexandre, Roth Andrew

Abstract excerpt

MOTIVATION: Cancer is driven by somatic mutations that result in the expansion of genomically distinct sub-populations of cells called clones. Identifying the clonal composition of tumours and understanding the evolutionary relationships between clones is a crucial task in cancer genomics. Bulk DNA sequencing is commonly used for studying the clonal composition of tumours, but it is challenging to infer the...

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PMID: 40511985
DOI: 10.1093/bioinformatics/btaf344
PMCID: PMC12964358

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