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Article

Power and pitfalls of computational methods for inferring clone phylogenies and mutation orders from bulk sequencing data.

Scientific reports - 26 Feb 2020

Miura Sayaka, Vu Tracy, Deng Jiamin, Buturla Tiffany, Oladeinde Olumide, Choi Jiyeong, Kumar Sudhir

Abstract excerpt

Tumors harbor extensive genetic heterogeneity in the form of distinct clone genotypes that arise over time and across different tissues and regions in cancer. Many computational methods produce clone phylogenies from population bulk sequencing data collected from multiple tumor samples from a patient. These clone phylogenies are used to infer mutation order and clone origins during tumor progression, rendering...

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Identifiers

PMID: 32103044
DOI: 10.1038/s41598-020-59006-2
PMCID: PMC7044161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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