Article

Chromatin remodeler Brahma safeguards canalization in cardiac mesoderm differentiation

2020-06-04

Abstract excerpt

<h4>SUMMARY</h4> Differentiation proceeds along a continuum of increasingly fate-restricted intermediates, referred to as canalization 1–4 . Canalization is essential for stabilizing cell fate, but the mechanisms underlying robust canalization are unclear. Here we show that deletion of the BRG1/BRM-associated factor (BAF) chromatin remodeling complex ATPase gene Brm (encoding Brahma) results in a radical identi...

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Literature Corpus work: 23936bd6-76da-5d5c-bbca-f4df8b20c3c1
DOI: 10.1101/2020.06.03.132654

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