Article

Opposing CTCF and GATA4 activities set the pace of chromatin topology remodeling during cardiomyogenesis

2025-10-07

Abstract excerpt

<h4>SUMMARY</h4> Reorganization of the three-dimensional chromatin structure is a critical feature of human embryonic development. Yet, the mechanisms regulating integrative remodelling of local structures (e.g., loops) and global architecture (e.g., A/B compartmentalization) remain un-clear. Here, we investigate this aspect in the context of cardiomyogenesis, characterized by pronounced B-to-A remodelling of sev...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 276ac939-f1ea-5ef5-8203-d43804aa921f
DOI: 10.1101/2025.10.07.680441

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Opposing CTCF and GATA4 activities set the pace of chromatin topology remodeling during cardiomyogenesisDOI 10.1101/2025.10.07.680441Read

Dynamics of Cardiomyocyte Transcriptome and Chromatin Landscape Demarcates Key Events of Heart DevelopmentSemantic proximity Read

Dynamic reorganization of nuclear architecture during human cardiogenesisSemantic proximity Read

Chromatin remodeler Brahma safeguards canalization in cardiac mesoderm differentiationSemantic proximity Read

Chromatin state transition underlies the temporal changes in gene expression during cardiomyocyte maturationSemantic proximity Read

Functional architecture of cardiac TF regulatory landscapes in control of mammalian heart developmentSemantic proximity Read

CHD-associated enhancers shape human cardiomyocyte lineage commitmentSemantic proximity Read

Single cell multiomics and 3D genome architecture reveal novel pathways of human heart failureSemantic proximity Read

Unique Transcription Factor Functions Regulate Epigenetic and Transcriptional Dynamics During Cardiac ReprogrammingSemantic proximity Read

Gene neighbourhood integrity disrupted by CTCF loss <i>in vivo</i>Semantic proximity Read

A cellular atlas of <i>Pitx2-</i>dependent cardiac developmentSemantic proximity Read

Spatial Dynamics of the Developing Human HeartSemantic proximity Read

The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heartSemantic proximity Read