Genetic and Epigenetic Control of Heart Development.

doi:10.1101/cshperspect.a036756

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Article

Genetic and Epigenetic Control of Heart Development.

Cold Spring Harbor perspectives in biology - 1 Jul 2020

Akerberg Brynn N, Pu William T

Abstract excerpt

A transcriptional program implemented by transcription factors and epigenetic regulators governs cardiac development and disease. Mutations in these factors are important causes of congenital heart disease. Here, we review selected recent advances in our understanding of the transcriptional and epigenetic control of heart development, including determinants of cardiac transcription factor chromatin occupancy, the...

Topics

Animals
Chromatin
Chromatin Assembly and Disassembly
DNA-Binding Proteins
Epigenesis, Genetic
Epigenomics
Exome
Gene Expression Regulation
Gene Regulatory Networks
Genome
Heart
Histones
Humans
Mutation
Nucleosomes
Organogenesis
Polycomb-Group Proteins
Transcription Factors

Source

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Identifiers

PMID: 31818853
DOI: 10.1101/cshperspect.a036756
PMCID: PMC7280077

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