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Article

Brg1 modulates enhancer activation in mesoderm lineage commitment.

Development (Cambridge, England) - 15 Apr 2015

Alexander Jeffrey M, Hota Swetansu K, He Daniel, Thomas Sean, Ho Lena, Pennacchio Len A, Bruneau Benoit G

Abstract excerpt

The interplay between different levels of gene regulation in modulating developmental transcriptional programs, such as histone modifications and chromatin remodeling, is not well understood. Here, we show that the chromatin remodeling factor Brg1 is required for enhancer activation in mesoderm induction. In an embryonic stem cell-based directed differentiation assay, the absence of Brg1 results in a failure of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25813539
DOI: 10.1242/dev.109496
PMCID: PMC4392595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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