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Article

Brahma safeguards canalization of cardiac mesoderm differentiation.

Nature - 1 Feb 2022

Hota Swetansu K, Rao Kavitha S, Blair Andrew P, Khalilimeybodi Ali, Hu Kevin M, Thomas Reuben, So Kevin, Kameswaran Vasumathi, Xu Jiewei, Polacco Benjamin J, Desai Ravi V, Chatterjee Nilanjana, Hsu Austin, Muncie Jonathon M, Blotnick Aaron M, Winchester Sarah A B, Weinberger Leor S, Hüttenhain Ruth, Kathiriya Irfan S, Krogan Nevan J, Saucerman Jeffrey J, Bruneau Benoit G

Abstract excerpt

Differentiation proceeds along a continuum of increasingly fate-restricted intermediates, referred to as canalization1,2. Canalization is essential for stabilizing cell fate, but the mechanisms that underlie robust canalization are unclear. Here we show that the BRG1/BRM-associated factor (BAF) chromatin-remodelling complex ATPase gene Brm safeguards cell identity during directed cardiogenesis of mouse embryonic...

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Share to Bone Morphogenetic Protein 4
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35082446
DOI: 10.1038/s41586-021-04336-y
PMCID: PMC9196993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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