Article

CHD-associated enhancers shape human cardiomyocyte lineage commitment

2022-04-10

Abstract excerpt

<h4>ABSTRACT</h4> Enhancers orchestrate gene expression programs that drive multicellular development and lineage commitment. Thus, genetic variants at enhancers are thought to contribute to developmental diseases by altering cell fate commitment. However, while many variant-containing enhancers have been identified, studies to endogenously test the impact of these enhancers on lineage commitment have been lackin...

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Literature Corpus work: 8e5fcf5a-a9be-5ef7-bbdd-350b04da6276
DOI: 10.1101/2022.04.07.487515

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