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Single cell transcriptomics uncovers a non-autonomous <i>Tbx1</i> -dependent genetic program controlling cardiac neural crest cell deployment and progression

2022-08-02

Abstract excerpt

Disruption of cardiac neural crest cells (CNCCs) results in congenital heart disease, yet we do not understand the cell fate dynamics as these cells differentiate to vascular smooth muscle cells. Here we utilized single-cell RNA-sequencing of NCCs from the pharyngeal apparatus with heart in control mouse embryos and when Tbx1 , the gene for 22q11.2 deletion syndrome, is inactivated. We uncovered three dynamic tra...

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Literature Corpus work
dcba8682-d11c-567f-9948-33cf52e31695
DOI
10.1101/2022.08.01.502391
Open publication

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Single cell transcriptomics uncovers a non-autonomous <i>Tbx1</i> -dependent genetic program controlling cardiac neural crest cell deployment and progressionDOI 10.1101/2022.08.01.502391
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