Article

Widespread link between DNA-packing density distribution and TAD boundary locations

2023-11-07

Abstract excerpt

<title>Abstract</title> <p>DNA is heterogeneously packaged into chromatin, which are further organized into Topologically associating domains (TADs) with sharp boundaries. The locations of TAD boundaries are critical for gene regulation. Here, we investigate whether the distribution of DNA-packing density along chromatin has an impact on the TAD boundary locations. We develop a polymer-physics-based model that ut...

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Literature Corpus work: 2244c4cf-a7f7-5dd6-b661-61b78c39e26d
DOI: 10.21203/rs.3.rs-3470944/v1

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