Article

3D genome architecture regulates the traffic of transcription factors throughout human chromosomes

2026-01-06

Abstract excerpt

Transcription factors (TFs) control the rate of transcription of genetic information by binding to specific DNA sequences. The time needed for a TF to find its specific target sites is a bottleneck to the genetic response mechanism. While TF target site search is a well studied problem, the effect of genome 3D architecture on the TF target search times is poorly understood. Here, we use accurate and cell-specific...

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Literature Corpus work: 742ef2c1-49e8-526c-b777-4db83c51384f
DOI: 10.64898/2026.01.06.698019

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