Article
Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele.
Journal of neuroinflammation - 20 Aug 2013
Dhungana Hiramani, Rolova Taisia, Savchenko Ekaterina, Wojciechowski Sara, Savolainen Kaisa, Ruotsalainen Anna-Kaisa, Sullivan Patrick M, Koistinaho Jari, Malm Tarja
Abstract excerpt
BACKGROUND: Numerous clinical trials in stroke have failed, most probably partially due to preclinical studies using young, healthy male rodents with little relevance to the heterogenic conditions of human stroke. Co-morbid conditions such as atherosclerosis and infections coupled with advanced age are known to contribute to increased risk of cerebrovascular diseases. Clinical and preclinical studies have shown...
Topics
- Aging
- Alleles
- Animals
- Apolipoprotein E4
- Atherosclerosis
- Comorbidity
- Diet, High-Fat
- Disease Models, Animal
- Genotype
- Humans