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More than just risk for Alzheimer's disease: APOE ε4's impact on the aging brain.

Trends in neurosciences - 1 Sept 2023

Palmer Justin M, Huentelman Matthew, Ryan Lee

Abstract excerpt

The apolipoprotein ε4 (APOE ε4) allele is most commonly associated with increased risk for late-onset Alzheimer's disease (AD). However, recent longitudinal studies suggest that these risks are overestimated; most ε4 carriers will not develop dementia in their lifetime. In this article, we review new evidence regarding the impact of APOE ε4 on cognition among healthy older adults. We discuss emerging work from...

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Aging
Alzheimer Disease
Apolipoprotein E4
Brain
Cognitive Dysfunction
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37460334
DOI: 10.1016/j.tins.2023.06.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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