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APOE4 expression confers a mild, persistent reduction in neurovascular function in the visual cortex and hippocampus of awake mice

2021-05-26

Abstract excerpt

Young mice possessing the e4 allele of the Apolipoprotein (APOE) gene (a risk factor for Alzheimer’s disease (AD)) have previously been shown to have dramatic decreases in vascular function, suggesting APOE4 may confer its risk via the vasculature. However, in human carriers, vascular and cognitive function decrease later in life. Mouse data may be confounded by an increased impact of anaesthesia and surgery in AP...

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Literature Corpus work
bed608fe-58c1-5950-8df1-bbcb5ae1f693
DOI
10.1101/2021.05.26.445731
Open publication

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APOE4 expression confers a mild, persistent reduction in neurovascular function in the visual cortex and hippocampus of awake miceDOI 10.1101/2021.05.26.445731
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