Article
APOE4 confers transcriptomic and functional alterations to primary mouse microglia.
Neurobiology of disease - 1 Mar 2022
Machlovi Saima I, Neuner Sarah M, Hemmer Brittany M, Khan Riana, Liu Yiyuan, Huang Min, Zhu Jeffrey D, Castellano Joseph M, Cai Dongming, Marcora Edoardo, Goate Alison M
Abstract excerpt
Common genetic variants in more than forty loci modulate risk for Alzheimer's disease (AD). AD risk alleles are enriched within enhancers active in myeloid cells, suggesting that microglia, the brain-resident macrophages, may play a key role in the etiology of AD. A major genetic risk factor for AD is Apolipoprotein E (APOE) genotype, with the ε4/ε4 (E4) genotype increasing risk for AD by approximately 15 fold...
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