Article

Impact of Apolipoprotein E4 on Blood-Brain Barrier Integrity in Target Replacement Murine Models: A Systematic Review and Meta-Analysis

2026-01-29

Abstract excerpt

<title>Abstract</title> <p> <underline> <italic>Background</italic> </underline> The E4 variant of Apolipoprotein E (APOE) is a primary genetic susceptibility risk factor for late-onset Alzheimer’s disease and has been implicated in cerebrovascular dysfunction. Preclinical mouse models are widely used to study <italic>APOE4</italic> , but cohesive understanding of APOE’s role is still inconsistent and lacki...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9bb83143-eaa0-5329-b50c-055dda7d2318
DOI: 10.21203/rs.3.rs-8011437/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impact of Apolipoprotein E4 on Blood-Brain Barrier Integrity in Target Replacement Murine Models: A Systematic Review and Meta-AnalysisDOI 10.21203/rs.3.rs-8011437/v1Read

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse modelsSemantic proximity Read

The role of APOE in cerebrovascular dysfunction.Semantic proximity Read

<i>APOE-</i> ε4-induced Fibronectin at the blood-brain barrier is a conserved pathological mediator of disrupted astrocyte-endothelia interaction in Alzheimer’s diseaseSemantic proximity Read

ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane ComponentsSemantic proximity Read

Detrimental Effects of ApoE ε4 on Blood–Brain Barrier Integrity and Their Potential Implications on the Pathogenesis of Alzheimer’s DiseaseSemantic proximity Read

A humanized Aβ mouse model reveals E4-dependent cognitive impairments, microglial activation, and cerebrovascular dysfunctionSemantic proximity Read

Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytesSemantic proximity Read

Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseasesSemantic proximity Read

Cell autonomous role of border associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injurySemantic proximity Read

APOE4 promotes cerebrovascular fibrosis and amyloid deposition via a pericyte-to-myofibroblast transitionSemantic proximity Read

Research progress on the role and mechanism of blood-brain barrier dysfunction in Alzheimer's diseaseSemantic proximity Read

The Impact of the Apolipoprotein E Genotype on Cardiovascular Disease and Cognitive Disorders.Semantic proximity Read