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Effects of APOE Genotype and Western Diet on Metabolic Phenotypes in Female Mice

16 Feb 2023

Abstract excerpt

Western diets high in sugars and saturated fats have been reported to induce metabolic and inflammatory impairments that are associated with several age-related disorders, including Alzheimer’s disease (AD) and type 2 diabetes (T2D). The apolipoprotein E (APOE) genotype is associated with metabolic and inflammatory outcomes that contribute to risks for AD and T2D, with the APOE4 genotype increasing risks relative...

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PMID: 36837905
DOI: 10.3390/metabo13020287

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