Article

Cross-species examination of X-chromosome inactivation highlights domains of escape from silencing

2020-12-06

Abstract excerpt

<h4>Background</h4> X-chromosome inactivation (XCI) in eutherian mammals is the epigenetic inactivation of one of the two X chromosomes in XX females in order to compensate for dosage differences with XY males. Not all genes are inactivated, and the proportion escaping from inactivation varies between human and mouse (the two species that have been extensively studied). <h4>Results</h4> We used DNA methylation t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2142c70c-0b59-52e4-98b0-0a90c4d5b8fe
DOI: 10.1101/2020.12.04.412197

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cross-species examination of X-chromosome inactivation highlights domains of escape from silencingDOI 10.1101/2020.12.04.412197Read

Cross-species examination of X-chromosome inactivation highlights domains of escape from silencingSemantic proximity Read

Contribution of epigenetic changes to escape from X-chromosome inactivationSemantic proximity Read

Contribution of genetic and epigenetic changes to escape from X-chromosome inactivationSemantic proximity Read

X-Chromosome Inactivation and Escape from X Inactivation in Mouse.Semantic proximity Read

Escape from X inactivation varies in mouse tissues.Semantic proximity Read

Mechanistic diversification of <i>XIST</i> regulatory network in mammalsSemantic proximity Read

Extensive remodelling of <i>XIST</i> regulatory networks during primate evolutionSemantic proximity Read

Landscape of X chromosome inactivation across human tissues.Semantic proximity Read

Landscape of X chromosome inactivation across human tissuesSemantic proximity Read

Whole-genome DNA methylomes of Tree shrew brains reveal conserved and divergent roles of DNA methylation on sex chromosome regulationSemantic proximity Read

Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.Semantic proximity Read

Cross-tissue analysis of allelic X-chromosome inactivation ratios resolves features of human developmentSemantic proximity Read