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Cross-species examination of X-chromosome inactivation highlights domains of escape from silencing

17 Feb 2021

Abstract excerpt

BACKGROUND: X-chromosome inactivation (XCI) in eutherian mammals is the epigenetic inactivation of one of the two X chromosomes in XX females in order to compensate for dosage differences with XY males. Not all genes are inactivated, and the proportion escaping from inactivation varies between human and mouse (the two species that have been extensively studied). RESULTS: We used DNA methylation to predict the XCI...

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PMID: 33597016
DOI: 10.1186/s13072-021-00386-8

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