Article

RESTRICT-seq enables time-gated CRISPR screens and uncovers novel epigenetic dependencies of SCC resistance

2025-09-20

Abstract excerpt

<h4>ABSTRACT</h4> Cancer cell evasion of therapy is a highly adaptive process that undermines the efficacy of many treatment strategies. A significant milestone in the study of these mechanisms has been the advent of pooled CRISPR knockout screens, which enable high-throughput, genome-wide interrogations of tumor dependencies and synthetic lethal interactions, advancing our understanding of how cancer cells adapt...

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Literature Corpus work: 21214130-ebee-510c-8c32-bbf4e7e7e2a0
DOI: 10.1101/2025.09.17.676440

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