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Article

Mapping convergent regulators of melanoma drug resistance by PerturbFate.

Nature - 1 Jun 2026

Xu Zihan, Lu Ziyu, Ugurbil Aileen, Abdulraouf Abdulraouf, Liao Andrew, Zhang Jianxiang, Zhou Wei, Cao Junyue

Abstract excerpt

High-throughput genomic studies have uncovered associations between diverse genetic alterations and disease phenotypes. However, elucidating how perturbations in functionally disparate genes give rise to convergent cellular states remains challenging. Here we present PerturbFate, a high-throughput, cost-effective, combinatorial-indexing single-cell platform that enables systematic interrogation of massively...

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Identifiers

PMID: 41986722
DOI: 10.1038/s41586-026-10367-0
PMCID: PMC13233327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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