Article

Uncovering Convergent Cell State Dynamics Across Divergent Genetic Perturbations Through Single-Cell High-Content CRISPR Screening

2025-05-05

Abstract excerpt

High-throughput genomic studies have uncovered associations between diverse genetic alterations and disease phenotypes; however, elucidating how perturbations in functionally disparate genes give rise to convergent cellular states remains challenging. Here, we present PerturbFate, a high-throughput, cost-effective, combinatorial-indexing single-cell platform that enables systematic interrogation of massively paral...

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Literature Corpus work: 93eba60a-b63f-5af2-8222-9bbdc2eb8c8c
DOI: 10.1101/2025.05.02.651939

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