Patient‐Derived Organoid‐Based <scp>CRISPR</scp> Screens in Cancer Research: Applications, Advances, and Challenges

Abstract excerpt

Patient-derived organoids (PDOs) have emerged as physiologically relevant cancer models that preserve key genetic, histological, and functional features of the tumors from which they are derived. In parallel, CRISPR-based perturbation technologies have transformed functional genomics by enabling scalable interrogation of gene function. Their integration provides a powerful framework for identifying cancer...

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