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Article

CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid leukemia samples.

Molecular cell - 5 Mar 2026

Cao Zhendong, Yu Sixiang, Peng Jacqueline, Barrett Declan R, Liu Yuqiao, Sussman Jonathan H, Chen Changya, Thadi Anusha, Liu Li, Alikarami Fatemeh, Xu Jason, Carroll Martin P, Tan Kai, Bernt Kathrin M, Shi Junwei

Abstract excerpt

Cancer functional genomics enables high-throughput target discovery and mechanistic investigation, yet its application has remained largely confined to mouse models and established human cancer cell lines. Direct functional interrogation of heterogeneous primary tumors offers a powerful opportunity to evaluate therapeutic targets and uncover cancer dependencies or resistance mechanisms. Here, we developed an...

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Identifiers

PMID: 41759529
DOI: 10.1016/j.molcel.2026.02.003
PMCID: PMC13036604

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