Article

EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities

2021-05-17

Abstract excerpt

<h4>ABSTRACT</h4> Dysregulation of the epigenome due to alterations in chromatin modifier proteins commonly contribute to malignant transformation. To discover new drug targets for more targeted and personalized therapies, functional interrogation of epigenetic modifiers is essential. We therefore generated an epigenome-wide CRISPR-Cas9 knock-out library (EPIKOL) that targets a wide-range of epigenetic modifiers...

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Literature Corpus work: f720111f-52d1-5256-bdad-6fc29826ae1f
DOI: 10.1101/2021.05.14.444239

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