Article

Optimized Repli-seq: Improved DNA Replication Timing Analysis by Next-Generation Sequencing

2022-04-27

Abstract excerpt

The human genome is divided into functional units that replicate at specific times during S-phase. This temporal program is known as replication timing (RT) and is coordinated with the spatial organization of the genome and transcriptional activity. RT is also cell type-specific, dynamically regulated during development, and alterations in RT are observed in multiple diseases. Thus, precise measure of RT is critic...

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Literature Corpus work: 23686b94-17b1-5047-bb30-5f28e2abf423
DOI: 10.1101/2022.04.26.489601

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